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Test Code CASF IgG/Albumin Ratio, Spinal Fluid

Reporting Name

IgG/Albumin Ratio, CSF

Useful For

Assessment of cerebrospinal fluid (CSF) IgG/albumin ratio in the absence of a paired CSF and serum specimen

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Ordering Guidance


The cerebrospinal fluid (CSF) index in which the CSF IgG/albumin ratio is compared to the serum IgG/albumin ratio aids in the diagnosis of individuals with multiple sclerosis. See SFIN / Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid.



Specimen Required


Collection Container/Tube: Sterile vial

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values

CSF IgG: 0.0-8.1 mg/dL

CSF albumin: 0.0-27.0 mg/dL

CSF IgG/albumin: 0.00-0.21

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82042

82784

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CASF IgG/Albumin Ratio, CSF 2470-3

 

Result ID Test Result Name Result LOINC Value
IGG_C IgG, CSF 2464-6
ALB_C Albumin, CSF 1746-7
AIGAC IgG/Albumin, CSF 2470-3

Method Description

The cerebrospinal fluid (CSF) and albumin are determined by immunonephelometry on a Siemens Nephelometer II. CSF IgG and albumin, and CSF IgG/albumin ratios are reported.(Instruction manual: Siemens Nephelometer II Operations. Siemens, Inc; Version 2.3, 2008; Addendum to the Instruction Manual 2.3, 08/2017)

Report Available

1 to 3 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Nephelometry

Secondary ID

8271