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HelpTest Code DHEA_ Dehydroepiandrosterone (DHEA), Serum
Reporting Name
Dehydroepiandrosterone, SUseful For
Diagnosing and differential diagnosis of hyperandrogenism (in conjunction with measurements of other sex steroids)
As an initial screen in adults with bioavailable testosterone measurement that may be supplemented with measurements of sex hormone-binding globulin and occasionally other androgenic steroids (eg, 17-hydroxyprogesterone), depending on results
An adjunct in the diagnosis of congenital adrenal hyperplasia (CAH); DHEA/DHEAS measurements play a secondary role to the measurements of cortisol/cortisone, 17 alpha-hydroxyprogesterone, and androstenedione
Diagnosing and differential diagnosis of premature adrenarche
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedNecessary Information
Patient's age and sex are required.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum to a plastic vial.
Additional Information: Requests for this test cannot be added to a previously received specimen.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Frozen (preferred) | 28 days | |
| Refrigerated | 21 days | ||
| Ambient | 6 hours |
Special Instructions
Reference Values
Premature: <40 ng/mL*
0-1 day: <11 ng/mL*
2-6 days: <8.7 ng/mL*
7 days-1 month: <5.8 ng/mL*
>1-23 months: <2.9 ng/mL*
2-5 years: <2.3 ng/mL
6-10 years: <3.4 ng/mL
11-14 years: <5.0 ng/mL
15-18 years: <6.6 ng/mL
19-30 years: <13 ng/mL
31-40 years: <10 ng/mL
41-50 years: <8.0 ng/mL
51-60 years: <6.0 ng/mL
≥61 years: <5.0 ng/mL
*Source: Dehydroepiandrosterone. In: Soldin SJ, Brugnara C, Wong Ed, eds. Pediatric Reference Ranges. 5th ed. AACC Press; 2005:75
For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) Performed
Monday, Thursday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82626
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DHEA_ | Dehydroepiandrosterone, S | 2193-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81405 | Dehydroepiandrosterone, S | 2193-1 |
Method Description
High Performance Liquid Chromatography with Triple Quad Tandem Mass Spectrometer.
Deuterated stable isotope ([D6]-DHEA) is added to a 0.4 mL serum sample as internal standard. The DHEA and internal standard are extracted from the sample by solid phase extraction. This is followed by conventional liquid chromatography on a Cohesive LX4 System and analysis on a tandem mass spectrometer equipped with a heated nebulizer ion source.(Unpublished Mayo Method)
Report Available
2 to 7 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Portions of this test are covered by patents held by Quest Diagnostics