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Test Code DRV2 Dilute Russell's Viper Venom Time (DRVVT) Mix, Plasma


Specimen Required


Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma


Secondary ID

602177

Useful For

Detecting the presence or helping to exclude the presence of lupus anticoagulants (LA)

 

Identifying LA that do not prolong the activated partial thromboplastin time (APTT)

 

Evaluating unexplained prolongation of the APTT or prothrombin time clotting tests

 

Distinguishing LA from a specific coagulation factor inhibitor or coagulation factor deficiencies

 

Confirmation of abnormal dilute Russell's viper venom time ratios

Method Name

Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma

 

Optical Clot-Based

Reporting Name

DRVVT Mix

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma

 

<1.20

Normal ranges for children: not clearly established, but similar to normal ranges for adults, except for newborn infants whose results may not reach adult values until 3 to 6 months of age.

Method Description

The dilute Russell's viper venom time (DRVVT) mix assay is performed on the Instrumentation Laboratory ACL TOP. Patient plasma is mixed in a 1:1 ratio with normal pooled plasma and incubated for a specified time, then combined with a DRVVT screening reagent containing Russell's viper venom, phospholipids, heparin neutralizing agents, calcium, buffers, stabilizers, and sodium azide to trigger the coagulation process. Subsequently, the time to clot formation is measured optically using a wavelength of 671 nm.

 

The patient DRVVT mix clotting time is normalized by dividing the patient result by the mean DRVVT screening clotting time of normal pooled plasma to yield a ratio.(Package insert: CRYOcheck LA Check, PrecisionBioLogic, Inc.; Insert I-021 Rev. 11)

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85613

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DRV2 DRVVT Mix 75512-4

 

Result ID Test Result Name Result LOINC Value
RVMR2 DRVVT Mix Ratio 75512-4

Day(s) Performed

Monday through Friday