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Test Code DRV3 Dilute Russell's Viper Venom Time (DRVVT) Confirmation, Plasma


Additional Testing Requirements


Serum anticardiolipin antibody testing (CLPMG / Phospholipid [Cardiolipin] Antibodies, IgG and IgM, Serum) and anti-beta-2 glycoprotein I (B2GMG / Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum) antibody testing should also be performed in conjunction with coagulation-based testing for lupus anticoagulants to enhance detection of different types of antiphospholipid antibodies.



Specimen Required


Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma


Secondary ID

602178

Useful For

Confirming the presence or absence of lupus anticoagulants (LA)

 

Identifying LA that do not prolong the activated partial thromboplastin time (APTT)

 

Evaluating unexplained prolongation of the APTT or prothrombin time clotting tests

 

Distinguishing LA from a specific coagulation factor inhibitor or coagulation factor deficiencies

Method Name

Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma

 

Optical Clot-Based

Reporting Name

DRVVT Confirmation

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Only orderable as part of a reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma

 

<1.20

Normal ranges for children: not clearly established, but similar to normal ranges for adults, except for newborn infants whose results may not reach adult values until 3 to 6 months of age.

Method Description

The dilute Russell viper venom time (DRVVT) confirmation assay is performed on the Instrumentation Laboratory ACL TOP. The assay is performed by incubating patient plasma for a specified time, then combining it with a DRVVT confirm reagent containing Russell viper venom, excess phospholipids, antiheparin agents, calcium, buffers, and stabilizers to trigger the coagulation process. The time to clot formation is measured optically using a wavelength of 671 nm.

 

The DRVVT confirmation is converted to a ratio by dividing the DRVVT screen clotting time by the DRVVT confirmation clotting time.(Package insert: CRYOcheck LA SURE dRVVT Confirmatory Reagent. Precision BioLogic; 05/2023)

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85613

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DRV3 DRVVT Confirmation 50410-0

 

Result ID Test Result Name Result LOINC Value
RVCR3 DRVVT Confirm Ratio 50410-0

Testing Algorithm

Dilute Russell's viper venom time (DRVVT) confirmation is only performed when the DRVVT screen is abnormally prolonged. Refer to DRV1 / Dilute Russell's Viper Venom Time (DRVVT), Plasma for interpretation of results.

Specimen Minimum Volume

See Specimen Required