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HelpTest Code HMU24 Heavy Metals Screen, with Reflex, 24 Hour, Urine
Specimen Required
1. For the 48-hour period prior to the start of collection, as well as during the collection, patient should not eat seafood.
2. High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic aliquot container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 6 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Secondary ID
48538Useful For
Detecting arsenic, cadmium, mercury, and lead exposure and toxicity using 24-hour urine specimens
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ASHU | Arsenic, 24 Hr, U | Yes, (order ASU24) | Yes |
| CDHMU | Cadmium, 24 Hr, U | Yes, (order CDU) | Yes |
| HGHU | Mercury, 24 Hr, U | Yes, (order HGU) | Yes |
| PBHU | Lead, 24 Hr, U | Yes, (order PBU) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SPASU | Arsenic Speciation, 24 Hr, U | Yes | No |
Testing Algorithm
If arsenic concentration is greater than or equal to 10 mcg/L, then speciation will be performed at an additional charge.
Special Instructions
Method Name
Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
Reporting Name
Heavy Metal Scrn w/Reflex, 24 Hr, USpecimen Type
UrineSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
ARSENIC:
0-17 years: Not established
≥18 years: <35 mcg/24 h
CADMIUM:
0-17 years: Not established
≥18 years: <0.7mcg/24 h
MERCURY:
0-17 years: Not established
≥18 years: <2 mcg/24 h
Toxic concentration: >50 mcg/24 h
The concentration at which toxicity is expressed is widely variable between patients.
50 mcg/24 h is the lowest concentration at which toxicity is usually apparent.
LEAD:
0-17 years: Not established
≥18 years: <2 mcg/24 h
Method Description
The metal analytes of interest are analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82175
82300
83825
83655
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HMU24 | Heavy Metal Scrn w/Reflex, 24 Hr, U | 94575-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8678 | Cadmium, 24 Hr, U | 5612-7 |
| 48539 | Arsenic, 24 Hr, U | 5587-1 |
| 92408 | Mercury, 24 Hr, U | 6693-6 |
| 92409 | Lead, 24 Hr, U | 5677-0 |
| TIME4 | Collection Duration | 13362-9 |
| 92215 | Total Arsenic Concentration | 21074-0 |
| VL16 | Total Volume | 3167-4 |