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Test Code PINS Proinsulin, Plasma

Reporting Name

Proinsulin, P

Useful For

As part of the diagnostic workup of suspected insulinoma

 

As part of the diagnostic workup of patients with suspected prohormone convertase 1/3 deficiency

 

As part of the diagnostic workup of patients with suspected proinsulin variations

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma EDTA


Specimen Required


Patient Preparation:

1.Patient should fast for 8 hours before specimen collection.

2. Infants younger than 2 years should fast a maximum of 6 hours.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Ice-cooled, lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. After collection, place the whole blood on ice for at least 10 minutes, then centrifuge at refrigerated temperature.

2. Aliquot plasma into a plastic vial and send frozen.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen 30 days

Reference Values

3.6-22 pmol/L

Day(s) Performed

Tuesday, Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84206

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PINS Proinsulin, P 27882-0

 

Result ID Test Result Name Result LOINC Value
80908 Proinsulin, P 27882-0

Method Description

Sequential 2-site electrochemiluminescent immunoassay performed on the MesoScale Discovery instrument. The assay uses a monoclonal biotinylated anti-insulin capture antibody and an anti-C-peptide detection antibody labeled with SULFO-TAG. The signal is directly proportional to the amount of proinsulin in the sample. Assay calibration is traceable to the World Health Organization 1st International Standard for human proinsulin, NIBSC code: 09/296. This assay demonstrates no cross-reactivity with insulin or C-peptide.(Unpublished Mayo method)

Report Available

2 to 5 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Method Name

Electrochemiluminescent Assay

Secondary ID

80908