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Test Code PTH-Intact Intact PTH

Aliases

Parathyroid Hormone Intact

Minimum Volume

  • Adult: 1 mL
  • Pediatric: 0.8 mL

Preferred Specimen

Plasma (K2 EDTA)

Acceptable Specimens

Serum:

  • Red top

Plasma:
  • Pink or Purple Top (K2/K3 EDTA)

Reference or Target Ranges

15 – 65 pg/mL

Reportable Units

pg/mL

Critical Value

Not defined for this assay

Reasons for Rejection



<!-- Rejection-->
Hemolysis Threshold
 250 mg/dL
Icterus Threshold
 40 mg/dL
Lipemia Threshold
 3000 mL
Other
 QNS, contaminated, improperly Labeled, improper specimen type

Specimen Stability



<!-- Stability -->
Ambient
 Plasma: 2 days
Serum: 8 hours
Refrigerated (4°C to 8°C)
 Plasma: 3 days
K2/K3-EDTA whole blood: 48 hours
Serum: 48 hours
Frozen(-40°C to 0°C)
 Plasma or Serum: 6 months

Performance Information



<!-- Performance information -->
Days and Time Performed
 24/7
Expected Turn Around Time
 Stat: 1 hour
Routine: 4 hours
Stat Availability
 Yes
Performing Bench
 UH Chemistry, WCH Chemistry
Methodology/Method Description
 Roche Cobas – Two site sandwich assay

Additional Information/Important Notes

Intraoperative PTH:
PTH has a reported half life of 3 – 5 minutes, a significant drop in PTH levels after resection of the abnormal gland or glands enables the surgeon to assess the completeness of resection and whether all hyperfunctioning parathyroid tissue has been removed from the patient. Baseline samples should be obtained pre-operation and pre-excision of the suspected hyperfunctioning gland. Specimens should be drawn at 5 and 10 minutes post resection and that a >50% reduction in PTH levels from the highest baseline be used as criteria for surgical success. Failure of PTH to drop below recommended levels indicates that either

  • Residual hyperfunctioning tissue is still present and further exploration may be necessary

  • or

  • A spike in PTH levels during adenoma mobilization occurred.
Intraoperative PTH measurements offer fast, reliable assessment when all hyperfunctioning parathyroid tissue has been removed during the surgical process.

CPT Codes

83970